Author Question: How are the primary mechanisms of most antidepressant drugs potentially related to the neurotrophic ... (Read 21 times)

fasfsadfdsfa

  • Hero Member
  • *****
  • Posts: 554
How are the primary mechanisms of most antidepressant drugs potentially related to the neurotrophic theory of mood disorders?
 
  What will be an ideal response?

Question 2

What are the primary clinical differences among the newer antidepressants, called selective serotonin reuptake inhibitors, and one of the oldest classes of antidepressants called the tricyclics?
 
  What will be an ideal response?



apple

  • Sr. Member
  • ****
  • Posts: 352
Answer to Question 1

Since serotonin and norepinephrine play pivotal roles in the homeostasis of neural tissue and protection or promotion of recovery from neural damage, antidepressants, by increasing monoaminergic activity (e.g., inhibiting reuptake or inhibiting monoamine inactivation), are proposed to enhance neurogenesis and neuronal growth (e.g., through stimulation of BDNF).

Answer to Question 2

Although the clinical efficacy of these two classes in terms of reducing the core symptoms of depression is equivalent, SSRIs produce far fewer disturbing side effects than tricyclics (e.g., sedation, anticholinergic effects, hypotension, cardiac effects, seizures, weight gain). The therapeutic index (the ratio of lethal dose to clinically effective dose) of SSRIs is much greater than with tricyclics, making them much more difficult to overdose on.



Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
 

Did you know?

Liver spots have nothing whatsoever to do with the liver. They are a type of freckles commonly seen in older adults who have been out in the sun without sufficient sunscreen.

Did you know?

There are approximately 3 million unintended pregnancies in the United States each year.

Did you know?

In 1864, the first barbiturate (barbituric acid) was synthesized.

Did you know?

In most climates, 8 to 10 glasses of water per day is recommended for adults. The best indicator for adequate fluid intake is frequent, clear urination.

Did you know?

The familiar sounds of your heart are made by the heart's valves as they open and close.

For a complete list of videos, visit our video library