Aripiprazole (Abilify) has been called a third-generation antipsychotic. What is a major difference in its pharmacological profile from that of 1st and 2nd generation antipsychotic drugs?
a. Abilify blocks 5-HT2A receptors, whereas 1st and 2nd generation antipsychotic drugs act as agonists at 5-HT2A receptors
b. Abilify blocks dopamine D2 receptors, whereas 1st and 2nd generation antipsychotic drugs act as agonists at dopamine D2 receptors
c. Abilify is a partial agonist at dopamine D2 receptors, whereas 1st and 2nd generation antipsychotic drugs act as antagonists or inverse agonists at dopamine D2 receptors
Question 2
The atypical antipsychotics risperidone (Risperdal) and olanzapine (Zyprexa), at low, clinically effective doses differ from conventional antipsychotics primarily in terms of their
a. degree of extrapyramidal motor disturbances induced
b. efficacy in reducing the negative symptoms of schizophrenia
c. efficacy in reducing the positive symptoms of schizophrenia
d. only a and b above
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