This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: What is a pharmacological reason for receptor down-regulation? What will be an ideal ... (Read 32 times)

javeds

  • Hero Member
  • *****
  • Posts: 570
on: Jun 22, 2018
What is a pharmacological reason for receptor down-regulation?
 
  What will be an ideal response?

Question 2

John Key has been injecting the drug Sopor to get high four to six times daily for a month. In addition to the euphoria experienced, the drug induces low blood pressure, low heart rate, pupillary constriction, and constipation.
 
  If John were to immediately stop taking Sopor, what might the abstinence syndrome look like and what would be its likely time course (described in terms of duration and intensity)?
 
  What will be an ideal response?


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

mirabriestensky

  • Sr. Member
  • ****
  • Posts: 325
Reply #1 on: Jun 22, 2018
Answer to Question 1

Greater than normal activity at receptors, either because a drug agonist activates them or the drug enhances the levels of the neurotransmitters for those receptors

Answer to Question 2

The abstinence syndrome would consist of effects generally opposite to the direct effects of the drug, e.g., dysphoria, high blood pressure, tachycardia, pupillary dilation, and diarrhea. Since it was necessary for John to take the drug this often to get high, it indicates that the drug was relatively shortacting; thus, withdrawal would likely to be relatively intense but short-lasting, e.g., a few days.


javeds

  • Member
  • Posts: 570
Reply 2 on: Jun 22, 2018
Excellent

EAN94

  • Member
  • Posts: 307
Reply 3 on: Yesterday
Gracias!

« previous next »
 

Did you know?

Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.

Did you know?

Astigmatism is the most common vision problem. It may accompany nearsightedness or farsightedness. It is usually caused by an irregularly shaped cornea, but sometimes it is the result of an irregularly shaped lens. Either type can be corrected by eyeglasses, contact lenses, or refractive surgery.

Did you know?

Although not all of the following muscle groups are commonly used, intramuscular injections may be given into the abdominals, biceps, calves, deltoids, gluteals, laterals, pectorals, quadriceps, trapezoids, and triceps.

Did you know?

Sperm cells are so tiny that 400 to 500 million (400,000,000–500,000,000) of them fit onto 1 tsp.

Did you know?

Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.

The Regulation of Skeletal Muscle Contraction The Regulation of Skeletal Muscle Contraction
Regulation of E. coli GS by covalent modification Regulation of E. coli GS by covalent modification
Eukaryotic Gene Exp and Regulation Eukaryotic Gene Exp and Regulation
The insulin receptor and its structural relationship to other transmembrane receptors with protein The insulin receptor and its structural relationship to other transmembrane receptors with protein
The 18 exons making up the gene encoding the LDL receptor protein The 18 exons making up the gene encoding the LDL receptor protein
lac operon transcription regulation lac operon transcription regulation
Video: Introduction to Sleep Apnea

For a complete list of videos, visit our video library