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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.
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The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The strongest synthetic topical retinoid drug available, tazarotene, is used to treat sun-damaged skin, acne, and psoriasis.
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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.