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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.

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Bacteria have flourished on the earth for over three billion years. They were the first life forms on the planet.

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Malaria was not eliminated in the United States until 1951. The term eliminated means that no new cases arise in a country for 3 years.

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In the United States, there is a birth every 8 seconds, according to the U.S. Census Bureau's Population Clock.

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