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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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In 2010, opiate painkllers, such as morphine, OxyContin®, and Vicodin®, were tied to almost 60% of drug overdose deaths.
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Recent studies have shown that the number of medication errors increases in relation to the number of orders that are verified per pharmacist, per work shift.
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Medication errors are three times higher among children and infants than with adults.