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Signs and symptoms of a drug overdose include losing consciousness, fever or sweating, breathing problems, abnormal pulse, and changes in skin color.

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The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.

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Acetaminophen (Tylenol) in overdose can seriously damage the liver. It should never be taken by people who use alcohol heavily; it can result in severe liver damage and even a condition requiring a liver transplant.

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The U.S. Preventive Services Task Force recommends that all women age 65 years of age or older should be screened with bone densitometry.

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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.

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Video: Wound Repair Animation

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