After reading the paragraph below, answer the questions that ...

[CORALGRILL2014]

After reading the paragraph below, answer the questions that follow.

As a scientist employed by the FDA, you've been asked to sit on a panel to evaluate a pharmaceutical company's application for approval of a new weight loss drug called Fat Away. The company has submitted a report summarizing the results of their animal and human testing. In the report, it was noted that Fat Away works by affecting the electron transport chain. It decreases the synthesis of ATP by making the mitochondrial membrane permeable to H+, which allows H+ to leak from the intermembrane space to the mitochondrial matrix. This effect leads to weight loss.

Fat Away prevents ATP from being made by
◦ preventing glycolysis from occurring.
◦ preventing the conversion of NADH to NAD+.
◦ slowing down the citric acid cycle.
◦ eliminating the H+ gradient that allows ATP synthase to work.

[joneynes]

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[CORALGRILL2014]

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[joneynes]

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