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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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There are over 65,000 known species of protozoa. About 10,000 species are parasitic.
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Patients who have been on total parenteral nutrition for more than a few days may need to have foods gradually reintroduced to give the digestive tract time to start working again.
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It is difficult to obtain enough calcium without consuming milk or other dairy foods.





