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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.

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Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.

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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.

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Though the United States has largely rejected the metric system, it is used for currency, as in 100 pennies = 1 dollar. Previously, the British currency system was used, with measurements such as 12 pence to the shilling, and 20 shillings to the pound.

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Studies show that systolic blood pressure can be significantly lowered by taking statins. In fact, the higher the patient's baseline blood pressure, the greater the effect of statins on his or her blood pressure.

Changes in light quality with depth: (a) the rich colours on a shallow coral reef; Changes in light quality with depth: (a) the rich colours on a shallow coral reef;
The dipolar nature of the H2O molecule The dipolar nature of the H2O molecule
Nature Nature
objective v subjective objective v subjective
Some scholars regard Walt Whitman as a poet of nature, and others, a poet of the body—a reference to Some scholars regard Walt Whitman as a poet of nature, and others, a poet of the body—a reference to
Hierarchical nature of hormone action in vertebrates Hierarchical nature of hormone action in vertebrates
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