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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
There are more bacteria in your mouth than there are people in the world.
Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.
If you could remove all of your skin, it would weigh up to 5 pounds.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.