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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
There are more sensory neurons in the tongue than in any other part of the body.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
Astigmatism is the most common vision problem. It may accompany nearsightedness or farsightedness. It is usually caused by an irregularly shaped cornea, but sometimes it is the result of an irregularly shaped lens. Either type can be corrected by eyeglasses, contact lenses, or refractive surgery.