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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Historic treatments for rheumatoid arthritis have included gold salts, acupuncture, a diet consisting of apples or rhubarb, nutmeg, nettles, bee venom, bracelets made of copper, prayer, rest, tooth extractions, fasting, honey, vitamins, insulin, snow collected on Christmas, magnets, and electric convulsion therapy.
Vaccines prevent between 2.5 and 4 million deaths every year.
Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
After 5 years of being diagnosed with rheumatoid arthritis, one every three patients will no longer be able to work.