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The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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According to the CDC, approximately 31.7% of the U.S. population has high low-density lipoprotein (LDL) or "bad cholesterol" levels.
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Excessive alcohol use costs the country approximately $235 billion every year.
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Illicit drug use costs the United States approximately $181 billion every year.