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By definition, when a medication is administered intravenously, its bioavailability is 100%.
The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
Illicit drug use costs the United States approximately $181 billion every year.