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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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About 3% of all pregnant women will give birth to twins, which is an increase in rate of nearly 60% since the early 1980s.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
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In 1864, the first barbiturate (barbituric acid) was synthesized.