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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
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Women are 50% to 75% more likely than men to experience an adverse drug reaction.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.