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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Opium has influenced much of the world's most popular literature. The following authors were all opium users, of varying degrees: Lewis Carroll, Charles, Dickens, Arthur Conan Doyle, and Oscar Wilde.
Approximately 500,000 babies are born each year in the United States to teenage mothers.
Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.