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The FDA recognizes 118 routes of administration.
Once thought to have neurofibromatosis, Joseph Merrick (also known as "the elephant man") is now, in retrospect, thought by clinical experts to have had Proteus syndrome. This endocrine disease causes continued and abnormal growth of the bones, muscles, skin, and so on and can become completely debilitating with severe deformities occurring anywhere on the body.
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.
Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.