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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
The first successful kidney transplant was performed in 1954 and occurred in Boston. A kidney from an identical twin was transplanted into his dying brother's body and was not rejected because it did not appear foreign to his body.
Multiple experimental evidences have confirmed that at the molecular level, cancer is caused by lesions in cellular DNA.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.