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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
All adults should have their cholesterol levels checked once every 5 years. During 2009–2010, 69.4% of Americans age 20 and older reported having their cholesterol checked within the last five years.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
In the United States, there is a birth every 8 seconds, according to the U.S. Census Bureau's Population Clock.