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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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There are approximately 3 million unintended pregnancies in the United States each year.
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Fewer than 10% of babies are born on their exact due dates, 50% are born within 1 week of the due date, and 90% are born within 2 weeks of the date.
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There are over 65,000 known species of protozoa. About 10,000 species are parasitic.