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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
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After 5 years of being diagnosed with rheumatoid arthritis, one every three patients will no longer be able to work.
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The FDA recognizes 118 routes of administration.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.
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