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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.
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On average, the stomach produces 2 L of hydrochloric acid per day.
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Women are 50% to 75% more likely than men to experience an adverse drug reaction.