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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.
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More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.
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In 2010, opiate painkllers, such as morphine, OxyContin®, and Vicodin®, were tied to almost 60% of drug overdose deaths.

