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Asthma cases in Americans are about 75% higher today than they were in 1980.
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The FDA recognizes 118 routes of administration.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.