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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Russia has the highest death rate from cardiovascular disease followed by the Ukraine, Romania, Hungary, and Poland.
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The FDA recognizes 118 routes of administration.
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Nitroglycerin is used to alleviate various heart-related conditions, and it is also the chief component of dynamite (but mixed in a solid clay base to stabilize it).
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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.