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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
An identified risk factor for osteoporosis is the intake of excessive amounts of vitamin A. Dietary intake of approximately double the recommended daily amount of vitamin A, by women, has been shown to reduce bone mineral density and increase the chances for hip fractures compared with women who consumed the recommended daily amount (or less) of vitamin A.
The FDA recognizes 118 routes of administration.
People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.