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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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The average adult has about 21 square feet of skin.
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Women are 50% to 75% more likely than men to experience an adverse drug reaction.
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On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.