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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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This year, an estimated 1.4 million Americans will have a new or recurrent heart attack.
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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
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Medication errors are three times higher among children and infants than with adults.
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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.