Author Question: Fragile X and Lesch-Nyhan syndromes are both caused by genetic abnormalities on the X chromosome. ... (Read 40 times)

Lobcity · **on:** Jun 22, 2018

Fragile X and Lesch-Nyhan syndromes are both caused by genetic abnormalities on the X chromosome. Explain the effects of these abnormalities for each disorder and discuss the prevalence rates among the sexes.

What will be an ideal response?

Question 2

Which of the following makes it possible to see all but the most minute abnormalities of brain structure?

a. CAT scan
b. EEG
c. MRI
d. PET scan

cupcake16 · **Reply #1 on:** Jun 22, 2018

Answer to Question 1

Fragile X syndrome (FXS) occurs when a DNA series makes too many copies of itself and turns off a gene on the X chromosome. When the gene is turned off, cells do not make a necessary protein, thus resulting in FXS. Symptoms of FXS include intellectual disability and behavioral disorders (e.g. hyperactivity, temper tantrums, irritability, and self-injurious behaviors). Perhaps because girls have 2 X chromosomes (that is, they have a spare X chromosome) they are only half as likely as boys to have FXS.
Lesch-Nyhan syndrome is a rare genetic disorder that is transmitted on the X chromosome. When the genetic defect is present, excess uric acid accumulates throughout the body. Lesch-Nyhan syndrome causes intellectual disability and behavioral problems (e.g., cognitive dysfunction, aggressive and impulsive behaviors, and persistent and severe self-injurious behaviors). Because it is a recessive trait, this disorder occurs only in boys.

Answer to Question 2

c. MRI