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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
Malaria was not eliminated in the United States until 1951. The term eliminated means that no new cases arise in a country for 3 years.
Human kidneys will clean about 1 million gallons of blood in an average lifetime.
By definition, when a medication is administered intravenously, its bioavailability is 100%.
Amphetamine poisoning can cause intravascular coagulation, circulatory collapse, rhabdomyolysis, ischemic colitis, acute psychosis, hyperthermia, respiratory distress syndrome, and pericarditis.