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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The longest a person has survived after a heart transplant is 24 years.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.