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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Acetaminophen (Tylenol) in overdose can seriously damage the liver. It should never be taken by people who use alcohol heavily; it can result in severe liver damage and even a condition requiring a liver transplant.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.