When CpG islands are unmethylated, ________.
◦ chromatin in the promoter region is open, allowing access by transcription factors and RNA polymerase
◦ chromatin in the promoter region is closed, preventing transcription factors and RNA polymerase from binding
◦ chromatin in the enhancer region is closed, so they are unable to bind regulatory proteins to initiate transcription
◦ DNAse hypersensitivity in that region of the chromosome is lost
◦ genes downstream of the CpG islands cannot be expressed, because the promoter region is blocked by histones
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