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Author Question: Many mutations in thebithoraxgene are known, such aspostbithorax,contrabithoraxandbithoriaxoid. Each ... (Read 56 times)

renzo156

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on: Jan 12, 2022
Many mutations in the bithorax gene are known, such as postbithorax, contrabithorax and bithoriaxoid.  Each mutation has a different effect on development of the reduced wing-like T3 appendage, the haltere.  None of these mutations occurs in the coding sequence of bithorax, instead, where are these mutations and how do they effect development?
◦ These mutations alter the slice sites for bithorax and affect the splicing of the bithorax mRNA.  Their different effects on development are cause by affects on alternative splicing.
◦ Each mutant alters a different codon within the bitorax gene, which affects the DNA-binding behavior of the bithorax protein.
◦ These mutations each effect silent sites and effect the stability of the bithorax mRNA.
◦ Bithorax is inhibited by zygotic genes from the mother and these mutations affect maternal genes.
◦ These mutations each effect a different enhancer(s) near the bithorax gene and the resulting misexpression of bithorax in each mutant causes patterning defects in the haltere.
Genetic Analysis: An Integrated Approach ¦ Sanders, Bowman ¦ 3rd Edition
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Marked as best answer by renzo156 on Jan 12, 2022

mjenn52

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Reply #1 on: Jan 12, 2022
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renzo156

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Reply 2 on: Jan 12, 2022
Great answer, keep it coming :)

okolip

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Reply 3 on: Yesterday
:D TYSM

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