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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
The oldest recorded age was 122. Madame Jeanne Calment was born in France in 1875 and died in 1997. She was a vegetarian and loved olive oil, port wine, and chocolate.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
Medication errors are more common among seriously ill patients than with those with minor conditions.