Question 1
Rank the following compounds in decreasing order (most to least) of reactivity towards a nucleophilic addition reaction.
◦ II > IV > V > III > I
◦ I > II > III > IV > V
◦ I > III > II > IV > V
◦ III > I > V > IV > II
◦ V > IV > II > III > I
Question 2
Aldehydes are more reactive than ketones towards nucleophilic addition reactions. Explain why.
◦ There is a steric effect in which the carbonyl group of the aldehyde produces a more sterically hindered transition state, but this is counteracted by an electronic effect because the carbonyl carbon of the aldehyde is more electrophilic.
◦ There is a steric effect in which the carbonyl group of the aldehyde produces a more sterically hindered transition state and an electronic effect because the carbonyl carbon of the aldehyde is more electrophilic.
◦ There is a steric effect in which the carbonyl group of the aldehyde produces a less sterically hindered transition state and an electronic effect because the carbonyl carbon of the aldehyde is more electrophilic.
◦ There is a steric effect in which the carbonyl group of the aldehyde produces a less sterically hindered transition state, but this is counteracted by an electronic effect because the carbonyl carbon of the aldehyde is more electrophilic.
◦ There is a steric effect in which the carbonyl group of the aldehyde produces a less sterically hindered transition state and an electronic effect because the carbonyl carbon of the aldehyde is less electrophilic.
Reactions 1 through 4 are necessary for the formation of each peptide bond.
Initial velocities of enzyme-catalyzed reactions
In addition to common schools, thousands of female seminaries were built between 1820 and 1850, many
Acid-Reactive Salts
Hydrolysis reactions for some biochemically important phosphate compounds (part 1)
Calculate KP for the following reactions at the indicated temperature.