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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
As many as 28% of hospitalized patients requiring mechanical ventilators to help them breathe (for more than 48 hours) will develop ventilator-associated pneumonia. Current therapy involves intravenous antibiotics, but new antibiotics that can be inhaled (and more directly treat the infection) are being developed.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.