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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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The ratio of hydrogen atoms to oxygen in water (H2O) is 2:1.
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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
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Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.

