Question 1
Which histone is most associated with linker DNA on the nucleosome?
◦ H1
◦ H2A
◦ H2B
◦ H3
◦ H4
Question 2
Which of the following best describes the effect of transcription on nucleosome structure in the transcribed region?
◦ Transcription proceeds through the histone structure and increases supercoiling.
◦ Transcription transiently displaces core histone octamers and decreases supercoiling.
◦ Transcription totally disrupts nucleosome structure.
◦ Transcription proceeds through the histone structure and decreases supercoiling.
◦ Transcription transiently displaces core histone octamers and increases supercoiling.