Introduction of a nonsense mutation in a eukaryotic protein coding gene often leads to:
◦ export of the mRNA from the cytoplasm.
◦ decreased ribosome binding in the cytoplasm to the mRNA due to its shorter size.
◦ increased degradation of the mRNA in the nucleus.
◦ increased degradation of the mRNA in the cytoplasm.
◦ retention of the mRNA in the nucleus so it is not translated.