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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Approximately 500,000 babies are born each year in the United States to teenage mothers.
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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.