|
|
Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Most fungi that pathogenically affect humans live in soil. If a person is not healthy, has an open wound, or is immunocompromised, a fungal infection can be very aggressive.
Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
In 1864, the first barbiturate (barbituric acid) was synthesized.

