Which of following is an expected finding in myelodysplastic ...

[Medesa]

Which of following is an expected finding in myelodysplastic syndromes?
 
  a. Ringed sideroblasts in the bone marrow and siderocytes in the blood
  b. Thrombocytosis and leukocytosis
  c. Increased number of morphologically normal red cells
  d. Dysmyelopoiesis but normal red cell precursors in the bone marrow

Question 2

Bone marrow or stem cell transplantation is the therapy of choice for patients younger than 55 years old with:
 
  a. Essential thrombocytosis
  b. Polycythemia vera
  c. Chronic myelogenous leukemia
  d. All of the above

[Rilsmarie951]

Answer to Question 1

ANS: A
Ringed sideroblasts and siderocytes in blood can be seen in myelodysplastic syndromes. Platelet and white counts are normal or decreased, red cell morphology is abnormal, and anemia is present. Dysmyelopoiesis and dyserythropoiesis are present in the bone marrow.

Answer to Question 2

ANS: C
Bone marrow or stem cell transplantation is the therapy of choice for patients younger than 55 years old with chronic myelogenous leukemia if an HLA-matched donor can be found. It is not a therapeutic choice for either essential thrombocytosis or polycythemia vera.