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Author Question: Select the metabolic pathway that converts toxic hydrogen peroxide produced by oxidant drugs to ... (Read 65 times)

bobbysung

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on: Jun 25, 2018
Select the metabolic pathway that converts toxic hydrogen peroxide produced by oxidant drugs to water:
 
  a. Embden-Meyerhof pathway (EMP)
  b. 2,3-Biphosphoglycerate (2,3-BPG)
  c. Methemoglobin reductase reaction
  d. Hexose monophosphate pathway

Question 2

What is the normal life span of a red cell in circulation?
 
  a. 2 Weeks
  b. 90 Days
  c. 120 Days
  d. 6 Months


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bfulkerson77

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Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: D
Hydrogen peroxide is an oxidant and is detoxified via the hexose monophosphate pathway using reduced glutathione. The EMP generates energy in the form of ATP; the 2,3-BPG pathway is a shunt off of the EMP that is important for the reversible binding of oxygen. Methemoglobin reductase is an enzyme that reduces the oxidized form of hemoglobin, called methemoglobin, to its reduced functional form.

Answer to Question 2

ANS: C
The normal red cell survives 120 days in circulation after its release from the bone marrow. By that time, changes that have occurred both internally and on the RBC membrane result in its phagocytosis and thus removal by splenic macrophages.


bobbysung

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Reply #2 on: Jun 25, 2018
Correct answers!


bfulkerson77

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Reply #3 on: Jun 25, 2018
Great! Please up vote :D


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