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Author Question: Explain the difference between the chemical composition of hemosiderin and that of ferritin. What ... (Read 23 times)

yoooooman

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on: Jun 25, 2018
Explain the difference between the chemical composition of hemosiderin and that of ferritin.
 
  What will be an ideal response?

Question 2

Explain how lead inhibits heme synthesis.
 
  What will be an ideal response?


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diesoon

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: Hemosiderin is an amalgam of iron, proteins, lipids, and carbohydrates. Ferritin is composed of polypeptides arranged in a spherical shell. Iron atoms are stored in the shell.

Answer to Question 2

Answer: Lead passes to the bone marrow where it accumulates in the mitochondria of erythroblasts and inhibits the enzymes involved in heme synthesis. RNA aggregates and mitochondria degenerates, forming basophilic stippling. Some aggregates contain free ionized iron. The enzymes most sensitive to lead are ALA-D and ferrocheletase.


yoooooman

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Reply 2 on: Jun 25, 2018
Wow, this really help

mohan

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Reply 3 on: Yesterday
Thanks for the timely response, appreciate it

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