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Author Question: What is the role of sex hormone binding globulin? How does SHBG play a role in PCOS? What will be ... (Read 116 times)

jasdeep_brar

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on: Jun 27, 2018
What is the role of sex hormone binding globulin? How does SHBG play a role in PCOS?
 
  What will be an ideal response?

Question 2

What is meant by unopposed estrogen?
 
  What will be an ideal response?


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trog

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Reply #1 on: Jun 27, 2018
Answer to Question 1

Sex hormone binding globulin binds to estradiol and testosterone in the blood, allowing only a small amount to circulate as free molecules (unbound). Unbound hormones are biologically active; hormones bound to SHBG are not active. The bioavailability (activity) of estradiol and testosterone are influenced by the levels of SHBG. PCOS is primarily a syndrome of increased testosterone activity in females. Decreased levels of SHBG cause free testosterone levels to be higher and thus more bioactive, resulting in virilization in females.

Answer to Question 2

Progesterone balances the effects of estrogen. Unopposed estrogen is an excess of estrogen that is not balanced or kept in check by progesterone.


jasdeep_brar

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Reply 2 on: Jun 27, 2018
Thanks for the timely response, appreciate it

raenoj

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Reply 3 on: Yesterday
:D TYSM

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