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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Thyroid conditions cause a higher risk of fibromyalgia and chronic fatigue syndrome.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Vaccines prevent between 2.5 and 4 million deaths every year.