Answer to Question 1
1
Rationale 1: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
Rationale 2: Selective estrogen-receptor modulators (SERMs) are used in the treatment of osteoporosis.
Rationale 3: Hormone replacement therapy (HT) is used for menopause.
Rationale 4: NSAIDs areused for a variety of inflammatory conditions.
Global Rationale: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
Answer to Question 2
1, 2, 3
Rationale 1: Rituximab (Rituxan) is used to treat rheumatoid arthritis.
Rationale 2: Leflunomide (Arava) is used to treat rheumatoid arthritis.
Rationale 3: Sulfasalazine (Azulfidine) is used to treat rheumatoid arthritis.
Rationale 4: Tizanidine (Zanaflex) is not used to treat rheumatoid arthritis.
Rationale 5: Ibuprofen (Advil) is not used to treat rheumatoid arthritis.
Global Rationale: Rituximab (Rituxan), Leflunomide (Arava),and Sulfasalazine (Azulfidine) are used to treat rheumatoid arthritis. Tizanidine (Zanaflex) is not used to treat rheumatoid arthritis. Ibuprofen (Advil) is not used to treat rheumatoid arthritis.
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